|Identification of recurrent and novel mutations in TULP1 in Pakistani families with early-onset retinitis pigmentosa. (Volume 18) - Ajmal, Muhammad|
This article is from Molecular Vision, volume 18.AbstractPurpose: To identify the genetic defects underlying retinitis pigmentosa (RP) in Pakistani families. Methods: Genome-wide high-density single-nucleotide-polymorphism microarray analysis was performed using the DNA of nine affected individuals from two large families with multiple consanguineous marriages. Data were analyzed to identify homozygous regions that are shared by affected sibs in each family...
|Exome sequencing identifies a novel and a recurrent BBS1 mutation in Pakistani families with Bardet-Biedl syndrome. (Volume 19) - Ajmal, Muhammad|
This article is from Molecular Vision, volume 19.AbstractPurpose: To determine the genetic cause of Bardet-Biedl syndrome (BBS) in two consanguineous Pakistani families. Methods: Clinical characterization of the affected individuals in both families was performed with ophthalmic examination, electroretinography, electrocardiography, and liver and renal profiling. Seventeen genes are known to be associated with BBS, so exome sequencing was preferred over candidate gene sequencing...
|Ninth annual report of the Association for the Religious Instruction of the Negroes in Liberty County : together with the address to the Association by the president the Rev. Robert Quarterman - Association for the Religious Instruction of the Negroes in Liberty County, Georgia|
"Published by order of the Association."
Keywords: African Americans; African Americans; African Americans; Religious education; Slaves
|Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population. (Volume 18) - Buentello-Volante, Beatriz|
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate the association of age-related macular degeneration (AMD)–high risk alleles of the complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), complement component 3 (C3), and age-related maculopathy susceptibility 2 (ARMS2) genes in a Mexican population for the first time. Methods: Genotyping was performed for the Y402H variant of CFH, for the L9H, R32Q, and K565E variants of CFB, the E318D...
|No association of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 or complement factor H polymorphisms with early age-related maculopathy in a Chinese cohort. (Volume 19) - Chen, Jian-Huan|
This article is from Molecular Vision, volume 19.AbstractPurpose: Single nucleotide polymorphisms (SNPs) of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 (ARMS2/HTRA1) and complement factor H (CFH) have been reported to be associated with age-related macular degeneration (AMD). The purpose of this study was to investigate the association of ARMS2/HTRA1 and CFH SNPs with early age-related maculopathy (ARM) in a Han Chinese cohort...
|Scleral structural alterations associated with chronic experimental intraocular pressure elevation in mice. (Volume 19) - Cone-Kimball, Elizabeth|
This article is from Molecular Vision, volume 19.AbstractPurpose: To study changes in scleral structure induced by chronic experimental intraocular pressure elevation in mice. Methods: We studied the effect of chronic bead-induced glaucoma on scleral thickness, collagen lamellar structure, and collagen fibril diameter distribution in C57BL/6 (B6) and CD1 mice, and in collagen 8α2 mutant mice (Aca23) and their wild-type littermates (Aca23-WT) using electron and confocal microscopy...
|Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs. (Volume 17) - Dong, Feng|
This article is from Molecular Vision, volume 17.AbstractPurpose: The dopamine (DA) system in the retina is critical to normal visual development as lack of retinal DA signaling may contribute to myopic development. The involvement of DA in myopic development is complex and may be different between form deprivation and hyperopic defocus. This study evaluated effects of a non-selective DA receptor agonist, apomorphine (APO) on refractive development in guinea pigs treated with form deprivation o...
|Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells. (Volume 17) - Gao, Shasha|
This article is from Molecular Vision, volume 17.AbstractPurpose: Epidemiological studies suggest that dietary intake of lutein and zeaxanthin is inversely related to the risk for senile cataract. The objectives of this work were to investigate the mechanisms by which these nutrients provide anti-cataract effects. We evaluated their modulation of oxidative damage in human lens epithelial cells (HLEC) and their interaction with intracellular glutathione (GSH)...
|Screening of RB1 gene mutations in Chinese patients with retinoblastoma and preliminary exploration of genotype-phenotype correlations. (Volume 20) - He, Ming-yan|
This article is from Molecular Vision, volume 20.AbstractPurpose: Retinoblastoma (RB) sets the paradigm for hereditary cancer syndromes, for which medical care can change depending on the results of genetic testing. In this study, we screened constitutional mutations in the RB1 gene via a method combining DNA sequencing and multiplex ligation-dependent probe amplification (MLPA), and performed a preliminary exploration of genotype–phenotype correlations...
|NGF promotes cell cycle progression by regulating D-type cyclins via PI3K/Akt and MAPK/Erk activation in human corneal epithelial cells. (Volume 18) - Hong, Jiaxu|
This article is from Molecular Vision, volume 18.AbstractPurpose: Nerve growth factor (NGF) plays an important role in promoting the healing of corneal wounds. However, the molecular mechanism by which NGF functions is unknown. We investigated the possible effects of NGF on phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and mitogen activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) pathways and cell growth in human corneal epithelial cells (HCECs)...
|Detecting genetic variations in hereditary retinal dystrophies with next-generation sequencing technology. (Volume 20) - Jin, Xin|
This article is from Molecular Vision, volume 20.AbstractPurpose: To identify pathogenic mutations responsible for retinal dystrophies (RDs) in three unrelated Chinese families. Methods: Three probands from unrelated families with RDs were recruited. Genomic DNA prepared from leukocytes was analyzed using gene chip–based next-generation sequencing (NGS) to capture and sequence all of the exons of 100 known RD-associated genes...
|Transcriptome analysis using next generation sequencing reveals molecular signatures of diabetic retinopathy and efficacy of candidate drugs. (Volume 18) - Kandpal, Raj P.|
This article is from Molecular Vision, volume 18.AbstractPurpose: To define gene expression changes associated with diabetic retinopathy in a mouse model using next generation sequencing, and to utilize transcriptome signatures to assess molecular pathways by which pharmacological agents inhibit diabetic retinopathy. Methods: We applied a high throughput RNA sequencing (RNA-seq) strategy using Illumina GAIIx to characterize the entire retinal transcriptome from nondiabetic and from streptozotoci...
|Three-dimensional architecture of collagen type VI in the human trabecular meshwork. (Volume 20) - Koudouna, Elena|
This article is from Molecular Vision, volume 20.AbstractPurpose: Type VI collagen is a primary component of the extracellular matrix of many connective tissues. It can form distinct aggregates depending on tissue structure, chemical environment, and physiology. In the current study we examine the ultrastructure and mode of aggregation of type VI collagen molecules in the human trabecular meshwork...
|Molecular analysis of the choroideremia gene related clinical findings in two families with choroideremia. (Volume 17) - Lin, Ying|
This article is from Molecular Vision, volume 17.AbstractPurpose: To investigate the choroideremia (CHM) gene in two families with CHM and to characterize the related clinical features. Methods: Two families underwent complete ophthalmic examinations and three males were diagnosed with CHM. Genomic DNA was extracted from the leukocytes of peripheral blood collected from the two families and from 100 unrelated control subjects from the same population...
|The tear film characteristics of spontaneous subconjunctival hemorrhage patients detected by Schirmer test I and tear interferometry. (Volume 18) - Liu, Wei|
This article is from Molecular Vision, volume 18.AbstractPurpose: To evaluate the tear film characteristics of spontaneous subconjunctival hemorrhage patients by Schirmer test I and tear interferometry. Methods: Forty-six spontaneous subconjunctival hemorrhage patients and 46 controls were enrolled in the study. Schirmer test I and tear interferometry were performed in all 92 subjects. The results obtained were compared between the two groups...
|Meta-analysis of association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-?2 gene and diabetic retinopathy in Caucasians and Asians. (Volume 18) - Ma, Jinlan|
This article is from Molecular Vision, volume 18.AbstractPurpose: The Pro12Ala polymorphism of the peroxisome proliferator–activated receptor-γ2 (PPARγ2) gene is reported to be associated with diabetes. However, the gene’s association with diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) has been investigated in numerous epidemiologic studies with controversial results. This meta-analysis aimed to collectively assess the association of the Pro12Ala polymorphism with DR in T2DM...
|Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma. (Volume 18) - Micheal, Shazia|
This article is from Molecular Vision, volume 18.AbstractPurpose: Single nucleotide polymorphisms (SNPs) rs1048661 (p.R141L) and rs3825942 (p.G153D) in the lysyl oxidase-like 1 (LOXL1) gene have been previously reported to be associated with pseudoexfoliation glaucoma (PEXG) in various Asian and European populations, but these SNPs have not yet been studied in the Pakistani population. Therefore the aim of the present study was to investigate the association of these two coding LOXL1 SNPs in Pak...
|Identification of a novel FBN1 gene mutation in a large Pakistani family with Marfan syndrome. (Volume 18) - Micheal, Shazia|
This article is from Molecular Vision, volume 18.AbstractPurpose: To describe a novel mutation in the fibrillin-1 (FBN1) gene in a large Pakistani family with autosomal dominant Marfan syndrome (MFS). Methods: Blood samples were collected of 11 family members affected with Marfan syndrome, and DNA was isolated by phenol-extraction. The coding exons of FBN1 were analyzed by polymerase chain reaction (PCR) and direct sequencing...
|Apelin-13 induces proliferation, migration, and collagen I mRNA expression in human RPE cells via PI3K/Akt and MEK/Erk signaling pathways. (Volume 19) - Qin, Dong|
This article is from Molecular Vision, volume 19.AbstractPurpose: Our previous study showed that apelin was increased in the vitreous and fibrotic membranes of patients with proliferative diabetic retinopathy (PDR) in vivo, which suggested that apelin may be involved in the development of PDR. In this study, we investigated whether the expression of apelin was upregulated in human retinal pigment epithelial (RPE) cells in vitro under high glucose conditions...
|Upregulation of DR3 expression in CD4+ T cells promotes secretion of IL-17 in experimental autoimmune uveitis. (Volume 17) - Qin, Tingyu|
This article is from Molecular Vision, volume 17.AbstractPurpose: This study investigated the role of death receptor 3 (DR3) in experimental autoimmune uveitis (EAU). Methods: EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161–180 emulsified with complete Freund’s adjuvant and evaluated with clinical and histopathologic observation...
|Calcineurin activation causes retinal ganglion cell degeneration. (Volume 18) - Qu, Juan|
This article is from Molecular Vision, volume 18.AbstractPurpose: We previously reported that calcineurin, a Ca2+/calmodulin-dependent serine/threonine phosphatase, is activated and proposed that it participates in retinal ganglion cell (RGC) apoptosis in two rodent ocular hypertension models. In this study, we tested whether calcineurin activation by itself, even in the absence of ocular hypertension, is sufficient to cause RGC degeneration...
|Different cellular effects of four anti-inflammatory eye drops on human corneal epithelial cells: independent in active components. (Volume 17) - Qu, Mingli|
This article is from Molecular Vision, volume 17.AbstractPurpose: To evaluate and compare the cellular effects of four commercially available anti-inflammatory eye drops and their active components on human corneal epithelial cells (HCECs) in vitro. Methods: The cellular effects of four eye drops (Bromfenac Sodium Hydrate Eye Drops, Pranoprofen Eye Drops, Diclofenac Sodium Eye Drops, and Tobramycin & Dex Eye Drops) and their corresponding active components were evaluated in an HCEC line with fiv...
|Elements of anatomy - Quain, Jones, 1796-1865|
Includes bibliographical references and index
Keywords: Anatomy; Anatomy
|Eternity in the heart : and other sermons - Quayle, William A. (William Alfred), 1860-1925|
Keywords: Methodist Church; Sermons, American
|The uncommon commonplace - Quayle, William A. (William Alfred), 1860-1925|
|Multimodal analysis of the progression of Best vitelliform macular dystrophy. (Volume 20) - Querques, Giuseppe|
This article is from Molecular Vision, volume 20.AbstractPurpose: To investigate the multimodal morphological features in the different stages of Best vitelliform macular dystrophy (VMD) in subjects harboring mutations in the BEST1 gene, and their changes during the progression of the disease. Methods: In this retrospective observational study performed between January 2007 and December 2012, 21 patients (42 eyes) with Best VMD from eight families with the BEST1 mutation were included...
|The astonishing history of Troy Town - Quiller-Couch, Arthur Thomas, Sir, 1863-1944|
Bound in illustrated paper-covered boards
|Rev. William F. Quillian, M.D . His life and sermons. - Quillian, Garnett W|
Keywords: Quillian, William Fletcher, 1843-1905
|The golden lamp: or, sketches upon the historic scenes, truths and characters of the Bible - Quillian, J. B. C|
|The Confederate soldiers' pocket manual of devotions - Quintard, C. T. (Charles Todd), 1824-1898, comp|
Parrish & Willingham. Confederate imprints
Keywords: Confederate States of America. Army; Armed Forces; Soldiers
|Mutational spectrum of the CYP1B1 gene in Pakistani patients with primary congenital glaucoma: Novel variants and genotype-phenotype correlations. (Volume 20) - Sheikh, Shakeel Ahmed|
This article is from Molecular Vision, volume 20.AbstractPurpose: This study aimed to investigate the role of CYP1B1 mutations in primary congenital glaucoma (PCG) in Pakistani patients. Methods: After consent was received, 20 families with at least more than one member affected with primary congenital glaucoma were enrolled in the study. The disease was confirmed with standard ophthalmological investigations...
|Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes. (Volume 19) - Tran-Viet, Khanh-Nhat|
This article is from Molecular Vision, volume 19.AbstractPurpose: Stickler syndrome is an arthro-ophthalmopathy with phenotypic overlap with Wagner syndrome. The common Stickler syndrome type I is inherited as an autosomal dominant trait, with causal mutations in collagen type II alpha 1 (COL2A1). Wagner syndrome is associated with mutations in versican (VCAN), which encodes for a chondroitin sulfate proteoglycan...
|XRCC1 and XPD DNA repair gene polymorphisms: A potential risk factor for glaucoma in the Pakistani population. (Volume 17) - Yousaf, Sajeela|
This article is from Molecular Vision, volume 17.AbstractPurpose: The present study was designed to determine the association of polymorphisms of the DNA repair genes X-ray cross-complementing group 1 (XRCC1) (c.1316G>A [rs25487]) and xeroderma pigmentosum complementation group D (XPD) (c.2298A>C [rs13181]) with primary open-angle glaucoma (POAG) and primary closed-angle glaucoma (PCAG). Methods: In this prospective case-control study, polymerase chain reaction-restriction fragment length polymo...
|A novel mutation in GJA3 associated with congenital Coppock-like cataract in a large Chinese family. (Volume 18) - Zhang, Lu|
This article is from Molecular Vision, volume 18.AbstractPurpose: To identify the potential pathogenic mutation over five generations of a Chinese family with congenital Coppock-like cataracts (CCL). Methods: We investigated five generations of a Chinese family affected with CCL. The family resides in a relatively isolated region of northern China. Peripheral blood samples were collected from all of the family members, and genomic DNA was then extracted from the blood samples...
|Increase in peripheral blood mononuclear cell Toll-like receptor 2/3 expression and reactivity to their ligands in a cohort of patients with wet age-related macular degeneration. (Volume 19) - Zhu, Yi|
This article is from Molecular Vision, volume 19.AbstractPurpose: To investigate Toll-like receptor (TLR) expression and reactivity in patients with the wet form age-related macular degeneration (AMD). Methods: Blood samples were collected from 25 patients with wet AMD and 25 age-matched healthy controls. Peripheral blood mononuclear cells (PBMCs) were isolated with Ficoll-Hypaque density gradient centrifugation...